Tsunade (綱手) is a descendant of the Senju and Uzumaki Clan, and is one of Konohagakure's Sannin. She is famed as the world's strongest kunoichi and its greatest medical-nin. The repeated loss of her loved ones caused Tsunade to later abandon the life of a shinobi for many years. She is eventually persuaded to return to Konoha and take on the mantle of Fifth Hokage where her skills prove invaluable to the village. Tsunade is the granddaughter of Hashirama Senju and Mito Uzumaki. Because Hashirama was the First Hokage of Konohagakure, Tsunade is called "Princess". Hashirama doted on Tsunade when she was very young because she was his first grandchild, and found her deviance and her adoption of his own gambling habits highly amusing. Tsunade inherited his necklace when he died. After she graduated from Konoha's Academy, Tsunade was teamed with Orochimaru and Jiraiya under the leadership of Hiruzen Sarutobi. When Jiraya failed to acquire a bell during the team's first bell test, Tsunade teased him, prompting him to criticise her flat chest. Despite this remark, Jiraiya had a certain interest in Tsunade from their first meeting, which only increased after her breasts developed; when she nearly killed him for spying on her while she bathed, he was forced to be more discrete about his interests.